Abstract
A method and composition for topically treating acne and acneiform dermal disorders includes applying an amount of a cephalosporin antibiotic effective to treat the acne and acneiform dermal disorders. The antibiotic is blended with a carrier suitable for topical application to dermal tissues. The carrier is selected from the group consisting of an aqueous liquid, an alcohol base, a water soluble gel, a lotion, an ointment, a nonaqueous liquid base, a mineral oil base, a blend of mineral oil and petrolatum, liposomes, a time-release patch, and a liquid-absorbed wipe. The cephalosporin can also be combined with benzoyl peroxide in a gel carrier.
Filing date: Sep 24, 1993
Issue date: Apr 25, 1995
Inventors: Howard N. Robinson, Neil F. Martin
Assignees: Marvin S. Towsend, Leonard Bloom
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What is claimed is:
1. A method of treating a human being for acne which comprises administering to the human being an amount of a composition consisting essentially of a cephalosporin antibiotic active ingredient selected from the group consisting of cefaclor, cefadroxil, cefamandole nafate, cefazolin, cefixime, cefmetazole, cefonioid, cefoperazone, ceforanide, cefotanme, cefotaxime, cefotetan, cefoxitin, cefpodoxime proxetil, ceftazidime, ceftizoxime, ceftriaxone, ceftriaxone moxalactam (a 1-oxa-beta-lactam), cefuroxime, cephalexin, cephalosporin C, cephalosporin C sodium salt, cephalothin, cephalothin sodium salt, cephapirin, cephradine, the 1-acetyloxy ethyl ester of cefuroxime (cefuroxime-axetil), dihydratecephalothin, moxalactam, and loracarbef and a pharmaceutical carrier, applied directly to affected dermal tissues, effective to treat the acne wherein said pharmaceutical carrier is a mixture of water and a water-miscible alcohol in amounts ranging from 42.2% to 99.5% of the composition.
2. The method described in claim 1 wherein the cephalosporin antibiotic is present in a range of from 0.5% to 10% by weight of the composition.
3. The method described in claim 1 wherein said water-miscible alcohol is ethyl alcohol in a weight percent range spanning 35% to 98.5%.
4. The method described in claim 1 wherein said water-miscible alcohol is isopropyl alcohol in a weight percent range spanning 4% to 80%.
5. The method described in claim 1 wherein said water-miscible alcohol is propylene glycol in a weight percent range spanning 3% to 26.8%.
6. The method described in claim 1 wherein said water is in a weight percent range spanning 9% to 95%.
7. The method described in claim 1 wherein said water-miscible alcohol is in a weight percent range spanning 11.2% to 90%.
8. A method of treating a human being for acne which comprises administering to the human being an amount of a composition consisting essentially of a cephalosporin antibiotic active ingredient selected from the group consisting of cefaclor, cefadroxil, cefamandole nafate, cefazolin, cefixime, cefmetazole, cefonicid, cefoperazone, ceforanide, cefotanme, cefotaxime, cefotetan, cefoxitin, cefpodoxime proxetil, ceftazidime, ceftizoxime, ceftriaxone, ceftriaxone moxalactam (a 1-oxa-beta-lactam), cefuroxime, cephalexin, cephalosporin C, cephalosporin C sodium salt, cephalothin, cephalothin sodium salt, cephapirin, cephradine, the 1-acetyloxy ethyl ester of cefuroxime (cefuroxime-axetil), dihydratecephalothin, moxalactam, and loracarbef, wherein said cephalosporin antibiotic is applied directly to affected dermal tissues in an amount effective to treat the acne, wherein said cephalosporin antibiotic is present in an amount in a range of 0.5-5% by weight and is applied in a carrier consisting essentially of:
- ethyl alcohol, in a range of 35-50% by weight,
- laureth-4, in a range of 0-1% by weight,
- isopropyl alcohol, in a range of 0-10% by weight, and
- water, in a range of 35-60% by weight.
9. The method described in claim 8 wherein said cephalosporin antibiotic is present in an amount of 2% by weight and is applied in a carrier consisting essentially of:
- ethyl alcohol, 41.5% by weight,
- laureth-4, 0.5% by weight,
- isopropyl alcohol, 6% by weight, and
- water, 50% by weight.
10. A method of treating a human being for acne which comprises administering to the human being an amount of a composition consisting essentially of a cephalosporin antibiotic active ingredient, which is cefaclor, and a pharmaceutical carrier, applied directly to affected dermal tissues, effective to treat the acne, wherein said pharmaceutical carrier is a mixture of water and a water-miscible alcohol in amounts ranging from 42.2% to 99.5% of the composition.
11. A method of treating a human being for acne which comprises the steps of:
- topically administering to affected dermal areas of the human being an amount of at least one conventionally topically applied anti-acne medication selected from the group consisting of benzoyl peroxide, sulfur, resorcinol, salicylic acid, and tretinoin in conventional doses, and
- topically administering to the affected dermal areas a composition which includes an amount of a cephalosporin antibiotic selected from the group consisting of cefaclor, cefadroxil, cefamandole nafate, cefazolin, cefixime, cefmetazole, cefonicid, cefoperazone, ceforanide, cefotanme, cefotaxime, cefotetan, cefoxitin, cefpodoxime proxetil, ceftazidime, ceftizoxime, ceftriaxone, ceftriaxone moxalactam (a 1-oxa-beta-lactam), cefuroxime, cephalexin, cephalosporin C, cephalosporin C sodium salt, cephalothin, cephalothin sodium salt, cephapirin, cephradine, the 1-acetyloxy ethyl ester of cefuroxime (cefuroxime-axetil), dihydratecephalothin, moxalactam, and loracarbef effective to treat the acne, and a pharmaceutical carrier, wherein said pharmaceutical carrier is a mixture of water and a water-miscible alcohol in amounts ranging from 42.2% to 99.5% of the composition.
12. The method described in claim 11 wherein the antibiotic is present in a range of 0.5% to 10% by weight of the composition.
13. A method of treating a human being for acne which comprises the steps of:
- topically administering to affected dermal areas of the human being an amount of at least one conventionally topically administered conventional anti-acne medication selected from the group consisting of benzoyl peroxide and tretinoin in conventional doses, and
- topically administering to the affected dermal areas an amount of a composition consisting essentially of a cephalosporin antibiotic active ingredient selected from the group consisting of cefaclor, cefadroxil, cefamandole nafate, cefazolin, cefixime, cefmetazole, cefonicid, cefoperazone, ceforanide, cefotanme, cefotaxime, cefotetan, cefoxitin, cefpodoxime proxetil, ceftazidime, ceftizoxime, ceftriaxone, ceftriaxone moxalactam (a 1-oxa-beta-lactam), cefuroxime, cephalexin, cephalosporin C, cephalosporin C sodium salt, cephalothin, cephalothin sodium salt, cephapirin, cephradine, the 1-acetyloxy ethyl ester of cefuroxime (cefuroxime-axetil), dihydratecephalothin, moxalactam, and loracarbef and a pharmaceutical carrier, effective to treat the acne, wherein the antibiotic is present in a range of 0.5% to 10% by weight of the composition, wherein said pharmaceutical carrier is a mixture of water and a water-miscible alcohol in amounts ranging from 42.2% to 99.5% of the composition.
14. The method described in claim 13 wherein the conventional anti-acne medication is benzoyl peroxide which is present in a range spanning 1% to 30% by weight.