Abstract
Esters and amides of all-trans-retinoic acid are disclosed which are useful for the treatment of acne.
Filing date: Aug 5, 1977
Issue date: Nov 21, 1978
Inventors: Robert J. Gander, John A. Gurney
Assignee: Johnson & Johnson
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What is claimed is:
1. N-(3,4-Methylenedioxyphenylmethyl)-all-trans-retinamide.
2. A pharmaceutical composition for the treatment of acne by topical application which comprises an effective acne-treatment amount of N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide admixed with a pharmaceutically-acceptable vehicle.
3. The composition of claim 2 wherein the N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide comprises from about 0.01% to about 0.5% by weight of the composition.
4. The composition of claim 3 wherein the N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide comprises from about 0.05% to about 0.2% by weight of the composition.
5. The composition of claim 2 wherein the vehicle is a mixture selected from the group consisting of propylene glycolethanol and propylene glycol-ethanol-chloroform.
6. A method for treatment of acne in a subject requiring such treatment which comprises topical application to the acne site of said subject of a composition comprising an effective acne-treatment amount of N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide admixed with a pharmaceutically-acceptable topical vehicle.
7. The method of claim 6 wherein the N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide comprises from about 0.01% to about 0.5% by weight of the composition.
8. The method of claim 7 wherein the N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide comprises from about 0.05% to about 0.2% by weight of the composition.
9. The method of claim 6 wherein the vehicle is a mixture selected from the group consisting of propylene glycolethanol and propylene glycol-ethanol-chloroform.