Abstract
A method of assisting weight loss involving the combined administration of a rauwolfia alkaloid and at least one antidepressant, selected from the groups consisting of aminoazoles, phenoxyphenylpropylamines, and aminopropiophenones, in a daily regimen with the optional co-administration of one or more sympathomimetic anorexic agents. In a typical embodiment of this method, reserpine and trazodone are administered in a daily regimen with diethylpropion, fenfluramine or both diethylpropion and fenfluramine.
Filing date: Sep 15, 1986
Issue date: Jan 23, 1990
Inventor: John C. Seed
Primary Examiner: Raymond J. Henley, III
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What is claimed is:
1. A method of assisting weight loss in a human in need thereof which comprises administering to said human, over a sustained period of time, both a rauwolfia alkaloid in the form of reserpine, and at least one antidepressant selected from the group consisting of trazodone, bupropion and fluoxetine in an administration regimen sufficient to supply effective daily dosages thereof for assisting weight loss.
2. The method of claim 1 wherein said antidepressant is trazodone and both reserpine and trazodone are administered concomitantly.
3. The method of claim 1 wherein the daily dosage of reserpine is between about 0.001 and about 0.01 milligram per kilogram of human body weight.
4. The method of claim 1 wherein said antidepressant is trazodone and the daily dosage of trazodone is between about 0.1 and about 6.0 milligram per kilogram of human body weight.
5. The method of claim 1 wherein said antidepressant is fluoxetine and both reserpine and fluoxetine are administered concomitantly.
6. The method of claim 1 wherein the daily dosage of reserpine is between about 0.001 and about 0.01 milligram per kilogram of human body weight.
7. The method of claim 1 wherein said antidepressant is fluoxetine and the daily dosage of fluoxetine is between about 0.1 and about 1.5 milligram per kilogram of human body weight.
8. The method of claim 1 wherein the rauwolfia alkaloid is reserpine, and both trazodone and fluoxetine are administered, said reserpine, trazodone, and fluoxetine being administered in a regimen sufficient to supply effective daily dosages thereof for assisting weight loss.
9. The method of claim 1 wherein the rauwolfia alkaloid is reserpine, and trazodone, bupropion, and fluoxetine are administered, said reserpine, trazodone, bupropion and fluoxetine being administered in a regimen sufficient to supply effective daily dosages thereof for assisting weight loss.
10. The method of claim 1 wherein the rauwolfia alkaloid is reserpine, and both trazodone and bupropion are administered, said reserpine, trazodone, and bupropion being administered in a regimen sufficient to supply effective daily dosages thereof for assisting weight loss.